ORGAN-SPECIFIC AND TISSUE-
SPECIFIC MANIFESTATIONS
IMPORTANT POINTS
When microbes affect the entire organ, such as lungs or kidneys, it is known as organ-specific manifestation. When the entire tissue is affected by the microbes, it is called a tissue-specific manifestation
The disease-causing microbes enter the body
through these different means.
Where do they
go then? The body is very large when
compared to the microbe
If they enter from the air
via the nose, they are likely to go to the lungs.
This is seen in the bacteria causing
tuberculosis. If they enter through the mouth,
they can stay in the gut lining like typhoid-
causing bacteria. Or they can go to the liver,
like the viruses that cause jaundice
An
infection like HIV, that comes into the body
via the sexual organs, will spread to lymphnodes all over the body.
The virus causing Japanese encephalitis,
or brain fever, will similarly enter through a
mosquito bite. But it goes on to infect the brain
MALARIA
Malaria is an acute febrile illness caused by Plasmodium parasites, which are spread to people through the bites of infected female Anopheles mosquitoes. There are 5 parasite species that cause malaria in humans, and 2 of these species
HUMAN IMMUNO DEFICIENCY VIRUS
HIV is caused by a virus. It can spread through sexual contact, illicit injection drug use or sharing needles, contact with infected blood, or from mother to child during pregnancy, childbirth or breastfeeding. HIV destroys CD4 T cells — white blood cells that play a large role in helping your body fight
CONCLUSION
From the above it is clear that It is also important to remember that the
severity of disease manifestations depend on
the number of microbes in the body.The immune system is a major
factor that determines the number of microbes surviving in the body.
